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In a review in breast most cancers cells, The mixture of lapatinib, a twin HER2/neu and EGFR tyrosine kinase inhibitor, with INK128 prevented each HER2 and HER3 phosphorylation induced by INK128 and produced synergistic induction of mobile Dying in different HER2-good mobile strains immune to trastuzumab and lapatinib. In vivoEarlier effectiveness